Royal Society of Chemistry, Chemical Communications, 63(50), p. 8761
DOI: 10.1039/c4cc03826f
Full text: Unavailable
National Basic Research Program (973 Program) of China [2010CB833200]; NSF of China [21332007, 20902075]; Program for Changjiang Scholars and Innovative Research Team in University (PCSIRT) of Ministry of Education, China ; We report one-pot and chemoselective Knoevenagel-type reactions using highly stable amides and lactams as the electrophilic substrates. The method is based on the in situ activation of amide carbonyl with triflic anhydride and a subsequent reaction with carbanions generated in situ from carbonyl compounds. The amide-based method is an alternative to the versatile thioamide-based Eschenmoser sulfide contraction.