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Royal Society of Chemistry, Catalysis Science & Technology, 5(3), p. 1198

DOI: 10.1039/c3cy20712a

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Non-canonical amino acids as a useful synthetic biological tool for lipase-catalysed reactions in hostile environments

Journal article published in 2013 by Carlos G. Acevedo-Rocha ORCID, Michael G. Hoesl, Sebastian Nehring, Marina Royter, Christina Wolschner, Birgit Wiltschi, Garabed Antranikian, Nediljko Budisa ORCID
This paper is made freely available by the publisher.
This paper is made freely available by the publisher.

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Abstract

The incorporation of several non-canonical amino acids into the Thermoanaerobacter thermohydrosulfuricus lipase confers not only activity enhancement upon treatment with organic solvents (by up to 450%) and surfactants (resp. 1630%), but also protective effects against protein reducing (resp. 140%), alkylating (resp. 160%), and denaturing (resp.190%) agents as well as inhibitors (resp. 40%). This approach offers novel chemically diversified biocatalysts for hostile environments. ; DFG, EXC 314, Unifying Concepts in Catalysis