Published in
Royal Society of Chemistry, Chemical Communications, 41(49), p. 4694
DOI: 10.1039/c3cc39076d
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P450 BM3 crystal structures reveal the role of the charged surface residue Lys/Arg184 in inversion of enantioselective styrene epoxidation
Journal article published in 2013 by
Aamir Shehzad,
Saravanan Panneerselvam,
Marina Linow,
Marco Bocola,
Danilo Roccatano,
Jochen Mueller-Dieckmann,
Matthias Wilmanns 
,
Ulrich Schwaneberg
,
Ulrich Schwaneberg
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Abstract
Solved crystal structures of P450 BM3 variants in complex with styrene provide on the molecular level a first explanation of how a positively charged surface residue inverts the enantiopreference of styrene epoxidation. The obtained insights into productive and non-productive styrene binding modes deepened our understanding of enantioselective epoxidation with P450 BM3.