Loci influencing lipid levels and coronary heart disease risk in 16 European population cohorts

van Duijn, Cornelia M.; Ys, Aulchenko; de Geus, Eco J. C.; Aulchenko, Yurii S.; Ripatti, Samuli; Lindqvist, Ida; Im, Heid; Boomsma, Dorret I.; Pp, Pramstaller; Heid, Iris M.; Pramstaller, Peter Pp; Bw, Penninx; Penninx, Brenda W. J. H.; Ac, Janssens; Janssens, Ac Cecile J. W.; Jf, Wilson; Wilson, James F.; Geus, E. J. C.; Spector, Tim; Cecile J. W. Janssens, A.; Martin, Nicholas G.; Ng, Martin; Pedersen, Nancy L.; Nl, Pedersen; Kyvik, Kirsten Ohm; Kaprio, Jaakko; Ko, Kyvik; Hofman, Albert; Freimer, Nelson B.; Jarvelin, Marjo-Riitta; Nb, Freimer; Gyllensten, Ulf; Campbell, Harry; Mr, Jarvelin; Rudan, Igor; Johansson, Å.; Johansson, Åsa; Marroni, Fabio; Hayward, Caroline; Vitart, Veronique; Jonasson, Inger; Pattaro, Cristian; Aa, Hicks; Wright, Alan; Hastie, Nick; Jj, Hottenga; Pichler, Irene; Ejc, de Geus; Hicks, Andrew Aa; Falchi, Mario; Willemsen, Gonneke; Gw, Montgomery; De Geus, E. J. C.; Ej, de Geus; Hottenga, Jouke-Jan; Ejg, Sijbrands; Montgomery, Grant W.; Whitfield, John; Magnusson, Patrik; Saharinen, Juha; Perola, Markus; Jcm, Witteman; Silander, Kaisa; Ag, Uitterlinden; Isaacs, Aaron; Ej, Sijbrands; Sijbrands, Eric J. G.; Ba, Oostra; Uitterlinden, Andre G.; Jc, Witteman; Witteman, Jacqueline C. M.; Duijn, C. M.; Oostra, Ben A.; Elliott, Paul; Ruokonen, Aimo; Sabatti, Chiara; Kronenberg, Florian; Gieger, Christian; He, Wichmann; Wichmann, He-Erich; Döring, Angela; Meitinger, Thomas; Jh, Smit; Smit, Johannes H.; McCarthy, Mark I.; Mi, McCarthy; Pattar, C.; Cm, van Duijn; Van Duijn, C. M.; Peltonen, Leena; Engage, Consortium; Janssen, A. C. J. W.

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Loci influencing lipid levels and coronary heart disease risk in 16 European population cohorts

Journal article published in 2008 by Cornelia M. van Duijn, Aulchenko Ys, Eco J. C. de Geus, Yurii S. Aulchenko, Samuli Ripatti, Ida Lindqvist, Heid Im, Dorret I. Boomsma, Pramstaller Pp, Iris M. Heid, Peter Pp Pramstaller, Penninx Bw, Brenda W. J. H. Penninx, Janssens Ac, Ac Cecile J. W. Janssens

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Abstract

Recent genome-wide association (GWA) studies of lipids have been conducted in samples ascertained for other phenotypes, particularly diabetes. Here we report the first GWA analysis of loci affecting total cholesterol (TC), low-density lipoprotein (LDL) cholesterol, high-density lipoprotein (HDL) cholesterol and triglycerides sampled randomly from 16 population-based cohorts and genotyped using mainly the Illumina HumanHap300-Duo platform. Our study included a total of 17,797-22,562 persons, aged 18-104 years and from geographic regions spanning from the Nordic countries to Southern Europe. We established 22 loci associated with serum lipid levels at a genome-wide significance level (P

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Loci influencing lipid levels and coronary heart disease risk in 16 European population cohorts

Abstract