Published in
Royal Society of Chemistry, Chemical Communications, 37(49), p. 3836
DOI: 10.1039/c3cc00127j
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Aptamer-targeted hyperbranched polymers: Towards greater specificity for tumours in vivo
Journal article published in 2013 by
Daniel J. Coles,
Barbara E. Rolfe 
,
Nathan Rb B. Boase,
Rakesh N. Veedu,
Kristofer J. Thurecht
,
Nathan Rb B. Boase,
Rakesh N. Veedu,
Kristofer J. Thurecht
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Abstract
Hyperbranched polymers conjugated to a peptide-aptamer were prepared using a combination of RAFT polymerisation and click chemistry for targeting tumour cells in vivo. The polymers showed enhanced cell-uptake in vitro (compared to unconjugated polymer) while excellent specificity for solid tumours was observed in vivo using a mouse model of melanoma.