Published in
Royal Society of Chemistry, Analyst, 9(149), p. 2738-2746, 2024
DOI: 10.1039/d4an00320a
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Conformational fingerprinting with Raman spectroscopy reveals protein structure as a translational biomarker of muscle pathology
Journal article published in 2024 by
James J. P. Alix 
,
Maria Plesia,
Alexander P. Dudgeon ,
Catherine A. Kendall,
Channa Hewamadduma,
Marios Hadjivassiliou,
Gráinne S. Gorman,
Robert W. Taylor,
Christopher J. McDermott,
Pamela J. Shaw,
Richard J. Mead,
John C. Day
,
Maria Plesia,
Alexander P. Dudgeon ,
Catherine A. Kendall,
Channa Hewamadduma,
Marios Hadjivassiliou,
Gráinne S. Gorman,
Robert W. Taylor,
Christopher J. McDermott,
Pamela J. Shaw,
Richard J. Mead,
John C. Day
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Abstract
Using a combination of peak fitting and matrix factorisation techniques we show that neuromuscular disease in both human biopsies and preclinical models manifests alterations in protein secondary structure. Created with biorender.com.