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Royal Society of Chemistry, RSC Medicinal Chemistry, 4(15), p. 1189-1197, 2024

DOI: 10.1039/d3md00609c

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A concept of dual-responsive prodrugs based on oligomerization-controlled reactivity of ester groups: an improvement of cancer cells versus neutrophils selectivity of camptothecin

Journal article published in 2024 by Insa Klemt ORCID, Viktor Reshetnikov, Subrata Dutta, Galyna Bila, Rostyslav Bilyy ORCID, Itziar Cossío Cuartero, Andrés Hidalgo, Adrian Wünsche, Maximilian Böhm, Marit Wondrak, Leoni A. Kunz-Schughart ORCID, Rainer Tietze ORCID, Frank Beierlein, Petra Imhof ORCID, Sabrina Gensberger-Reigl ORCID and other authors.
This paper was not found in any repository, but could be made available legally by the author.
This paper was not found in any repository, but could be made available legally by the author.

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Abstract

We introduced a concept of prodrugs activated by H2O2 and mitochondrial OH−, which is applicable to camptothecin and its derivatives.