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Royal Society of Chemistry, Soft Matter, 3(20), p. 693-703, 2024

DOI: 10.1039/d3sm01332d

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Deciphering the influence of Y12L and N17H substitutions on the conformation and oligomerization of human calcitonin

Journal article published in 2024 by Jiajia Yan, Ying Wang, Xinjie Fan, Yu Zou ORCID, Feng Ding ORCID, Fengjuan Huang, Yunxiang Sun ORCID
This paper was not found in any repository, but could be made available legally by the author.
This paper was not found in any repository, but could be made available legally by the author.

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Abstract

Monomers of hCT primarily adopted dynamic helical structures and readily aggregated into β-sheet-rich oligomers and β-barrel intermediates. The Y12L and N17H mutations enhanced helical conformations and partially inhibited the helix-to-β conversion.