Published in
Royal Society of Chemistry, Reaction Chemistry and Engineering, 12(8), p. 3203-3209, 2023
DOI: 10.1039/d3re00342f
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Sustainable continuous flow synthesis of β-aminocarbonyls via acid-catalyzed hydration of N-Boc-2-azetines
Journal article published in 2023 by
Michael Andresini 
,
Marco Colella ,
Roberta Savina Dibenedetto,
Elena Graziano,
Giuseppe Romanazzi ,
Andrea Aramini ,
Leonardo Degennaro ,
Renzo Luisi
,
Marco Colella ,
Roberta Savina Dibenedetto,
Elena Graziano,
Giuseppe Romanazzi ,
Andrea Aramini ,
Leonardo Degennaro ,
Renzo Luisi
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Abstract
In this work we report a waste-minimized continuous flow process for the synthesis of β-aminocarbonyls through hydration of N-Boc-2-azetines promoted under acid-catalysed conditions.