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Royal Society of Chemistry, Organic and Biomolecular Chemistry, 42(21), p. 8535-8547, 2023

DOI: 10.1039/d3ob00906h

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β-Peptides incorporating polyhydroxylated cyclohexane β-amino acid: synthesis and conformational study

Journal article published in 2023 by David Reza ORCID, Rosalino Balo ORCID, José M. Otero, Ai M. Fletcher, Rebeca García-Fandino ORCID, Víctor M. Sánchez-Pedregal ORCID, Stephen G. Davies ORCID, Ramón J. Estévez ORCID, Juan C. Estévez ORCID
This paper was not found in any repository, but could be made available legally by the author.
This paper was not found in any repository, but could be made available legally by the author.

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Abstract

We describe the synthesis of trihydroxylated cyclohexane β-amino acids from (−)-shikimic acid, in their cis and trans configuration, and the incorporation of the trans isomer into a trans-2-aminocyclohexanecarboxylic acid peptide chain.