Published in
Royal Society of Chemistry, Chemical Science, 26(14), p. 7262-7278, 2023
DOI: 10.1039/d2sc06858c
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High-throughput screen with the l,d-transpeptidase Ldt<sub>Mt2</sub> of Mycobacterium tuberculosis reveals novel classes of covalently reacting inhibitors
Journal article published in 2023 by
Mariska de Munnik 
,
Pauline A. Lang ,
Francisco De Dios Anton,
Mónica Cacho ,
Robert H. Bates ,
Jürgen Brem ,
Beatriz Rodríguez Miquel ,
Christopher J. Schofield
,
Pauline A. Lang ,
Francisco De Dios Anton,
Mónica Cacho ,
Robert H. Bates ,
Jürgen Brem ,
Beatriz Rodríguez Miquel ,
Christopher J. Schofield
This paper is made freely available by the publisher.
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Abstract
10 000 electrophilic compounds were screened for inhibition of the essential l,d-transpeptidase (LdtMt2) of Mycobacterium tuberculosis. Potent covalently reacting inhibitors were identified and characterised by protein X-ray and MS studies.