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Royal Society of Chemistry, Nanoscale, 16(13), p. 7667-7677, 2021

DOI: 10.1039/d0nr09200b

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Binding of tyrosine kinase inhibitor to epidermal growth factor receptor: surface-enhanced infrared absorption microscopy reveals subtle protein secondary structure variations

This paper was not found in any repository, but could be made available legally by the author.
This paper was not found in any repository, but could be made available legally by the author.

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Data provided by SHERPA/RoMEO

Abstract

Mid-IR plasmonic device for SEIRA microscopy allowed to reveal the subtle conformational changes associated with the binding of Lapatinin inhibitor to the kinase domain of EGFR receptor, a well-known driver of tumorigenesis in pathological settings.