Published in
Royal Society of Chemistry, Nanoscale, 16(13), p. 7648-7666, 2021
DOI: 10.1039/d0nr09153g
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Gold nanoparticles (AuNPs) impair LPS-driven immune responses by promoting a tolerogenic-like dendritic cell phenotype with altered endosomal structures
Journal article published in 2021 by
Sara Michelini 
,
Francesco Barbero ,
Alessandra Prinelli,
Philip Steiner,
Richard Weiss ,
Thomas Verwanger,
Ancuela Andosch,
Ursula Lütz-Meindl,
Victor F. Puntes ,
Damjana Drobne ,
Albert Duschl ,
Jutta Horejs-Hoeck
,
Francesco Barbero ,
Alessandra Prinelli,
Philip Steiner,
Richard Weiss ,
Thomas Verwanger,
Ancuela Andosch,
Ursula Lütz-Meindl,
Victor F. Puntes ,
Damjana Drobne ,
Albert Duschl ,
Jutta Horejs-Hoeck
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Abstract
This study shows that gold nanoparticles promote the differentiation of dendritic cells to a tolerogenic-like phenotype, affecting their ability to induce antibacterial immune responses mediated by Th1 cells and to activate central memory T cells.