Published in
Royal Society of Chemistry, Organic and Biomolecular Chemistry, 29(19), p. 6501-6512, 2021
DOI: 10.1039/d1ob01015h
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Synthesis, characterization, and cellular investigations of porphyrin– and chlorin–indomethacin conjugates for photodynamic therapy of cancer
Journal article published in 2021 by
José Almeida 
,
Guanyu Zhang,
Maodie Wang,
Carla Queirós ,
Ana F. R. Cerqueira ,
Augusto C. Tomé ,
Giampaolo Barone ,
M. Graça H. Vicente ,
Evamarie Hey-Hawkins ,
Ana M. G. Silva ,
Maria Rangel
,
Guanyu Zhang,
Maodie Wang,
Carla Queirós ,
Ana F. R. Cerqueira ,
Augusto C. Tomé ,
Giampaolo Barone ,
M. Graça H. Vicente ,
Evamarie Hey-Hawkins ,
Ana M. G. Silva ,
Maria Rangel
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Abstract
The efficient synthesis of porphyrin– and chlorin–NSAID conjugates, and their singlet oxygen generation capacity and HEp2 cell toxicity are reported.