Published in
Royal Society of Chemistry, RSC Medicinal Chemistry, 10(12), p. 1709-1721, 2021
DOI: 10.1039/d1md00168j
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It takes two to tango: synthesis of cytotoxic quinones containing two redox active centers with potential antitumor activity
Journal article published in 2021 by
Daisy J. B. Lima 
,
Renata G. Almeida ,
Guilherme A. M. Jardim ,
Breno P. A. Barbosa,
Augusto C. C. Santos ,
Wagner O. Valença ,
Marcos R. Scheide ,
Claudia C. Gatto ,
Guilherme G. C. de Carvalho,
Pedro M. S. Costa ,
Claudia Pessoa ,
Cynthia L. M. Pereira ,
Claus Jacob ,
Antonio L. Braga ,
Eufrânio N. da Silva Júnior
,
Renata G. Almeida ,
Guilherme A. M. Jardim ,
Breno P. A. Barbosa,
Augusto C. C. Santos ,
Wagner O. Valença ,
Marcos R. Scheide ,
Claudia C. Gatto ,
Guilherme G. C. de Carvalho,
Pedro M. S. Costa ,
Claudia Pessoa ,
Cynthia L. M. Pereira ,
Claus Jacob ,
Antonio L. Braga ,
Eufrânio N. da Silva Júnior
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Abstract
Quinone-based frameworks with antitumor activities were described. We identified compounds with IC50 values below 0.5 μM in cancer cells lines with significantly lower cytotoxicity in the control cell line L929.