Published in
Royal Society of Chemistry, Dalton Transactions, 2(51), p. 491-508, 2022
DOI: 10.1039/d1dt03553c
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Impact of the ferrocenyl group on cytotoxicity and KSP inhibitory activity of ferrocenyl monastrol conjugates
Journal article published in 2022 by
Anna Wieczorek-Błauż 
,
Karolina Kowalczyk,
Andrzej Błauż ,
Anna Makal,
Sylwia Pawlędzio ,
Chatchakorn Eurtivong ,
Homayon J. Arabshahi,
Jóhannes Reynisson ,
Christian G. Hartinger ,
Błażej Rychlik ,
Damian Plażuk
,
Karolina Kowalczyk,
Andrzej Błauż ,
Anna Makal,
Sylwia Pawlędzio ,
Chatchakorn Eurtivong ,
Homayon J. Arabshahi,
Jóhannes Reynisson ,
Christian G. Hartinger ,
Błażej Rychlik ,
Damian Plażuk
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Abstract
Introduction of the ferrocenyl group into the monastrol scaffold improved the cytotoxic activity, and increased the kinesin-spindle-protein (KSP) inhibitory activity and its ability to generate ROS which led to increased levels of apoptotic cells.