Published in
Royal Society of Chemistry, Chemical Communications, 12(58), p. 1962-1965, 2022
DOI: 10.1039/d1cc06766d
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Divinylpyrimidine reagents generate antibody–drug conjugates with excellent in vivo efficacy and tolerability
Journal article published in 2022 by
Stephen J. Walsh 
,
Soleilmane Omarjee ,
Friederike M. Dannheim ,
Dominique-Laurent Couturier ,
Dorentina Bexheti,
Lee Mendil,
Gemma Cronshaw,
Toby Fewster,
Charlotte Gregg,
Cara Brodie,
Jodi L. Miller ,
Richard Houghton,
Jason S. Carroll ,
David R. Spring
,
Soleilmane Omarjee ,
Friederike M. Dannheim ,
Dominique-Laurent Couturier ,
Dorentina Bexheti,
Lee Mendil,
Gemma Cronshaw,
Toby Fewster,
Charlotte Gregg,
Cara Brodie,
Jodi L. Miller ,
Richard Houghton,
Jason S. Carroll ,
David R. Spring
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Abstract
The development of divinylpyrimidine (DVP) reagents for the synthesis of antibody–drug conjugates (ADCs) with in vivo efficacy and tolerability is reported.