Published in
Royal Society of Chemistry, Nanoscale, 9(14), p. 3452-3466, 2022
DOI: 10.1039/d1nr08429a
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Triggering the nanophase separation of albumin through multivalent binding to glycogen for drug delivery in 2D and 3D multicellular constructs
Journal article published in 2022 by
Agata Radziwon 
,
Sukhvir K. Bhangu ,
Soraia Fernandes ,
Christina Cortez-Jugo ,
Robert De Rose ,
Brendan Dyett ,
Marcin Wojnilowicz ,
Petra Laznickova ,
Jan Fric ,
Giancarlo Forte ,
Frank Caruso ,
Francesca Cavalieri
,
Sukhvir K. Bhangu ,
Soraia Fernandes ,
Christina Cortez-Jugo ,
Robert De Rose ,
Brendan Dyett ,
Marcin Wojnilowicz ,
Petra Laznickova ,
Jan Fric ,
Giancarlo Forte ,
Frank Caruso ,
Francesca Cavalieri
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Abstract
Nanocomplexes of glycogen nanoparticles with serum albumin were formed by triggering the nanophase separation of albumin. The nanocomplexes enabled the delivery of chemotherapeutics in complex multicellular 3D tumour-like structures.