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Royal Society of Chemistry, Natural Product Reports, 1(40), p. 46-61, 2023

DOI: 10.1039/d2np00014h

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Structure-based engineering of α-ketoglutarate dependent oxygenases in fungal meroterpenoid biosynthesis

Journal article published in 2023 by Takayoshi Awakawa ORCID, Takahiro Mori, Richiro Ushimaru, Ikuro Abe ORCID
This paper is made freely available by the publisher.
This paper is made freely available by the publisher.

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Abstract

The α-ketoglutarate dependent oxygenases catalyze remarkable chemistries in polyketide-derived fungal meroterpenoid biosynthesis. This review summarizes recent progress in the structure-based engineering of these enzymes.