Published in
Royal Society of Chemistry, Chemical Communications, 5(47), p. 1503-1505
DOI: 10.1039/c0cc02901g
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The binding of CNA35 contrast agents to collagen fibrils
Journal article published in 2011 by
Hmhf Erik Sanders,
Honorius M. H. F. Sanders,
Michele Iafisco,
Em Emilie Pouget,
Emilie M. Pouget,
Phh Paul Bomans,
Paul H. H. Bomans,
Fabio Nudelman,
Giuseppe Falini,
G. Bert de With,
Maarten Merkx,
Gj Gustav Strijkers 
,
Gustav J. Strijkers,
K. Klaas Nicolaij,
Klaas Nicolay
and other authors.
,
Gustav J. Strijkers,
K. Klaas Nicolaij,
Klaas Nicolay
and other authors.
This paper is available in a repository.
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Abstract
CryoTEM demonstrates that a CNA35-bearing liposomal MRI contrast agent selectively binds to poorly assembled collagen type I as opposed to well-assembled collagen fibrils, whereas monomeric CNA35 binds to all forms of collagen. It is shown that upon conjugation to liposomes and micelles CNA35 loses its ability to dissociate ordered collagen fibrils and thereby to create its own binding sites.