Published in
Royal Society of Chemistry, Biomaterials Science, 16(10), p. 4612-4626, 2022
DOI: 10.1039/d2bm00403h
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Spatial delivery of immune cues to lymph nodes to define therapeutic outcomes in cancer vaccination
Journal article published in 2022 by
James I. Andorko 
,
Shannon J. Tsai,
Joshua M. Gammon,
Sean T. Carey ,
Xiangbin Zeng,
Emily A. Gosselin,
Camilla Edwards ,
Shrey A. Shah,
Krystina L. Hess,
Christopher M. Jewell
,
Shannon J. Tsai,
Joshua M. Gammon,
Sean T. Carey ,
Xiangbin Zeng,
Emily A. Gosselin,
Camilla Edwards ,
Shrey A. Shah,
Krystina L. Hess,
Christopher M. Jewell
This paper is made freely available by the publisher.
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Abstract
Local signal integration in lymph nodes (LNs) controls the potency and selectivity of immune responses. Here, intra-LN depots were used to direct communication within treated LNs, causing programmable and divergent systemic immunotherapy outcomes.