Published in
Royal Society of Chemistry, Chemical Communications, 63(58), p. 8858-8861, 2022
DOI: 10.1039/d2cc02094g
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Targeting the deubiquitinase USP7 for degradation with PROTACs
Journal article published in 2022 by
Arunima Murgai 
,
Izidor Sosič ,
Martina Gobec ,
Patricia Lemnitzer ,
Matic Proj ,
Sophie Wittenburg ,
Rabea Voget,
Michael Gütschow ,
Jan Krönke,
Christian Steinebach
,
Izidor Sosič ,
Martina Gobec ,
Patricia Lemnitzer ,
Matic Proj ,
Sophie Wittenburg ,
Rabea Voget,
Michael Gütschow ,
Jan Krönke,
Christian Steinebach
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Abstract
A novel class of USP7 PROTACs were designed and synthesized. CST967, a CRBN-based degrader, showed potent and selective depletion of USP7 leading to apoptosis in multiple cancer lines.