Published in
Royal Society of Chemistry, Physical Chemistry Chemical Physics, 36(24), p. 21773-21785, 2022
DOI: 10.1039/d2cp02851d
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Molecular insights into the oligomerization dynamics and conformations of amyloidogenic and non-amyloidogenic amylin from discrete molecular dynamics simulations
Journal article published in 2022 by
Ying Wang,
Yuying Liu,
Yu Zhang,
Guanghong Wei 
,
Feng Ding ,
Yunxiang Sun
,
Feng Ding ,
Yunxiang Sun
This paper is made freely available by the publisher.
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Abstract
hIAPP and hIAPP(S20G) could spontaneously assemble into β-sheet-rich oligomers and β-barrel formations, and the β-barrel propensity of hIAPP(S20G) was three times larger than that of hIAPP. rIAPP predominantly nucleated into helix-abundant structures.