Published in
Royal Society of Chemistry, Chemical Communications, 78(58), p. 10933-10936, 2022
DOI: 10.1039/d2cc03092f
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Light-mediated multi-target protein degradation using arylazopyrazole photoswitchable PROTACs (AP-PROTACs)
Journal article published in 2022 by
Qisi Zhang 
,
Cyrille S. Kounde ,
Milon Mondal ,
Jake L. Greenfield ,
Jennifer R. Baker ,
Sergei Kotelnikov ,
Mikhail Ignatov,
Christopher P. Tinworth ,
Leran Zhang ,
Daniel Conole ,
Elena De Vita ,
Dima Kozakov ,
Adam McCluskey ,
John D. Harling ,
Matthew J. Fuchter
and other authors.
,
Cyrille S. Kounde ,
Milon Mondal ,
Jake L. Greenfield ,
Jennifer R. Baker ,
Sergei Kotelnikov ,
Mikhail Ignatov,
Christopher P. Tinworth ,
Leran Zhang ,
Daniel Conole ,
Elena De Vita ,
Dima Kozakov ,
Adam McCluskey ,
John D. Harling ,
Matthew J. Fuchter
and other authors.
This paper is made freely available by the publisher.
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Abstract
A new class of arylazopyrazole photoswitchable PROTACs (AP-PROTACs) enables light-triggered degradation of a specific ensemble of protein kinases.