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Royal Society of Chemistry, Chemical Communications, 85(58), p. 11913-11916, 2022

DOI: 10.1039/d2cc03135c

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Ligand-based drug repurposing strategy identified SARS-CoV-2 RNA G-quadruplex binders

Journal article published in 2022 by Federica Moraca ORCID, Simona Marzano ORCID, Francesco D'Amico ORCID, Antonio Lupia, Silvia Di Fonzo ORCID, Eleonora Vertecchi, Erica Salvati, Anna Di Porzio, Bruno Catalanotti, Antonio Randazzo ORCID, Bruno Pagano ORCID, Jussara Amato ORCID
This paper was not found in any repository, but could be made available legally by the author.
This paper was not found in any repository, but could be made available legally by the author.

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Abstract

Ligand-based virtual screening and biophysical techniques have been used to identify FDA approved drugs able to bind and stabilize SARS-CoV-2 G-quadruplex-forming RNA and to provide the molecular basis of the interactions.