Published in
Royal Society of Chemistry, RSC Medicinal Chemistry, 12(13), p. 1549-1564, 2022
DOI: 10.1039/d2md00163b
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Fragment optimization and elaboration strategies – the discovery of two lead series of PRMT5/MTA inhibitors from five fragment hits
Journal article published in 2022 by
Christopher R. Smith 
,
Svitlana Kulyk,
Misbha Ud Din Ahmad ,
Valentina Arkhipova,
James G. Christensen,
Robin J. Gunn,
Anthony Ivetac,
John M. Ketcham,
Jon Kuehler,
J. David Lawson ,
Nicole C. Thomas,
Xiaolun Wang,
Matthew A. Marx
,
Svitlana Kulyk,
Misbha Ud Din Ahmad ,
Valentina Arkhipova,
James G. Christensen,
Robin J. Gunn,
Anthony Ivetac,
John M. Ketcham,
Jon Kuehler,
J. David Lawson ,
Nicole C. Thomas,
Xiaolun Wang,
Matthew A. Marx
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Abstract
Herein we describe our approach to prioritize five fragment hits with the objective of answering three questions: could the binding potency be improved? Were the series chemically tractable? Could additional co-crystal structures be solved?