Published in
Royal Society of Chemistry, Nanoscale Horizons, 12(7), p. 1540-1552, 2022
DOI: 10.1039/d2nh00331g
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Multiplexed molecular imaging with surface enhanced resonance Raman scattering nanoprobes reveals immunotherapy response in mice via multichannel image segmentation
Journal article published in 2022 by
Chrysafis Andreou 
,
Konstantinos Plakas,
Naxhije Berisha,
Mathieu Gigoux,
Lauren E. Rosch,
Rustin Mirsafavi,
Anton Oseledchyk,
Suchetan Pal ,
Dmitriy Zamarin,
Taha Merghoub,
Michael R. Detty,
Moritz F. Kircher
,
Konstantinos Plakas,
Naxhije Berisha,
Mathieu Gigoux,
Lauren E. Rosch,
Rustin Mirsafavi,
Anton Oseledchyk,
Suchetan Pal ,
Dmitriy Zamarin,
Taha Merghoub,
Michael R. Detty,
Moritz F. Kircher
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Abstract
Multiplexed imaging of 8 molecular targets with SERS nanoprobes in mice reveals spatially heterogeneous tumor responses to immunotherapy. Multichannel image segmentation enables classification of the tumor regions into responders and naïve.