Published in
Royal Society of Chemistry, Chemical Society Reviews, 22(51), p. 9243-9261, 2022
DOI: 10.1039/d2cs00362g
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Applications of covalent chemistry in targeted protein degradation
Journal article published in 2022 by
Dong Lu 
,
Xin Yu,
Hanfeng Lin ,
Ran Cheng,
Erika Y. Monroy ,
Xiaoli Qi,
Meng C. Wang,
Jin Wang
,
Xin Yu,
Hanfeng Lin ,
Ran Cheng,
Erika Y. Monroy ,
Xiaoli Qi,
Meng C. Wang,
Jin Wang
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Abstract
This review summarizes the recent work of covalent chemistry in targeted protein degradation and describes the concept, pros and cons, development, and the outlook of covalent PROTACs.