Published in
Royal Society of Chemistry, Organic and Biomolecular Chemistry, 12(21), p. 2509-2515, 2023
DOI: 10.1039/d3ob00128h
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A potent fluorescent transmembrane HCl transporter perturbs cellular pH and promotes cancer cell death
Journal article published in 2023 by
Mohamed Fares,
Xin Wu 
,
Daniel A. McNaughton,
Alexander M. Gilchrist ,
William Lewis,
Paul A. Keller ,
Alain Arias-Betancur,
Pere Fontova,
Ricardo Pérez-Tomás,
Philip A. Gale
,
Daniel A. McNaughton,
Alexander M. Gilchrist ,
William Lewis,
Paul A. Keller ,
Alain Arias-Betancur,
Pere Fontova,
Ricardo Pérez-Tomás,
Philip A. Gale
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Abstract
A series of fluorescent coumarin-based bis-ureas have been synthesised. These compounds show strong HCl cotransport properties in model vesicle systems. Cellular localisation studies show that cytotoxic compound 4 localises in lysosomes and perturbs cellular pH.