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Royal Society of Chemistry, Chemical Communications, 16(59), p. 2243-2246, 2023

DOI: 10.1039/d2cc06850h

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Pre-targeting amyloid-β with antibodies for potential molecular imaging of Alzheimer's disease

Journal article published in 2023 by Katherine A. Morgan ORCID, Michael de Veer ORCID, Luke A. Miles, Cormac A. A. Kelderman ORCID, Catriona A. McLean, Colin L. Masters, Kevin J. Barnham, Jonathan M. White ORCID, Brett M. Paterson ORCID, Paul S. Donnelly ORCID
This paper was not found in any repository, but could be made available legally by the author.
This paper was not found in any repository, but could be made available legally by the author.

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Abstract

Amyloid-β antibodies were modified to incorporate trans-cyclooctene functional groups. Radiolabeled copper-64 probes, which can cross the blood–brain barrier and contain a 1,2,4,5-tetrazine functional group, react with the modified antibodies.