Published in
Royal Society of Chemistry, Food and Function, 15(14), p. 7247-7269, 2023
DOI: 10.1039/d3fo00122a
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Ketogenic diet attenuates neuroinflammation and induces conversion of M1 microglia to M2 in an EAE model of multiple sclerosis by regulating the NF-κB/NLRP3 pathway and inhibiting HDAC3 and P2X7R activation
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Abstract
In EAE, KD inhibits demyelination, neuroinflammation and chemokines/chemokine receptors, and promotes M1 to M2 switching in microglia, as demonstrated by the TLR4/NF-κB/HDAC3/P2X7R/NLRP3 pathway and the JAK1/STAT1 pathway.