Published in
Royal Society of Chemistry, Chemical Communications, 90(59), p. 13490-13493, 2023
DOI: 10.1039/d3cc04448c
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Supramolecular intermediates in thermo-mechanochemical direct amidations
Journal article published in 2023 by
Tomislav Stolar 
,
Jasna Alić ,
Gregor Talajić ,
Nikola Cindro ,
Mirta Rubčić ,
Krešimir Molčanov,
Krunoslav Užarević ,
José G. Hernández
,
Jasna Alić ,
Gregor Talajić ,
Nikola Cindro ,
Mirta Rubčić ,
Krešimir Molčanov,
Krunoslav Užarević ,
José G. Hernández
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Abstract
We present a solvent-free thermo-mechanochemical approach for the direct coupling of carboxylic acids and amines, which avoids activators and additives. Non-covalent interactions between the reagents guide the formation of the amide bond.