Published in
Royal Society of Chemistry, Dalton Transactions, 34(52), p. 11835-11849, 2023
DOI: 10.1039/d3dt01815f
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Stretching the chains: the destabilizing impact of Cu<sup>2+</sup> and Zn<sup>2+</sup> ions on K48-linked diubiquitin
Journal article published in 2023 by
Vincenzo Mangini 
,
Giulia Grasso,
Benny Danilo Belviso ,
Michele F. M. Sciacca ,
Valeria Lanza ,
Rocco Caliandro ,
Danilo Milardi
,
Giulia Grasso,
Benny Danilo Belviso ,
Michele F. M. Sciacca ,
Valeria Lanza ,
Rocco Caliandro ,
Danilo Milardi
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Abstract
Cu2+ and Zn2+ ions play distinct roles in destabilizing the K48-Ub2 structure, causing separation of the ubiquitin monomers and highlighting their potential to interfere with Ub signalling.