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Royal Society of Chemistry, Dalton Transactions, 34(52), p. 11859-11874, 2023

DOI: 10.1039/d3dt01217d

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Organometallic Ru, Os, Rh and Ir half-sandwich conjugates of ispinesib – impact of the organometallic group on the antimitotic activity

This paper was not found in any repository, but could be made available legally by the author.
This paper was not found in any repository, but could be made available legally by the author.

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Abstract

Conjugating Ru, Os, Rh, and Ir half-sandwich with ispinesib enhanced cytotoxicity. Ru and Rh complexes generate ROS, indicating alternative modes of action beyond KSP inhibition.