Published in
Royal Society of Chemistry, Dalton Transactions, 30(52), p. 10338-10347, 2023
DOI: 10.1039/d3dt01836a
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Cobalt bis(dicarbollide) is a DNA-neutral pharmacophore
Journal article published in 2023 by
Krzysztof Fink 
,
Jakub Cebula,
Zdeněk Tošner,
Mateusz Psurski,
Mariusz Uchman ,
Tomasz M. Goszczyński
,
Jakub Cebula,
Zdeněk Tošner,
Mateusz Psurski,
Mariusz Uchman ,
Tomasz M. Goszczyński
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Abstract
Cobalt bis(dicarbollide) (COSAN) is a DNA-neutral pharmacophore without significant interactions with DNA. As a result, DNA is not necessary for COSAN to induce cytotoxicity, which is most likely protein- or cell membrane-dependent.