Published in
Royal Society of Chemistry, Chemical Communications, 33(57), p. 4031-4034, 2021
DOI: 10.1039/d1cc00932j
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VCD spectroscopy reveals that a water molecule determines the conformation of azithromycin in solution
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Abstract
Despite the large and flexible structure of azithromycin, VCD spectroscopy is sensitive to a single molecule of water incorporated in the hydrogen bonding network above the macrocycle.