Published in
Royal Society of Chemistry, Analyst, 15(147), p. 3464-3469, 2022
DOI: 10.1039/d2an00978a
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Detection of paracetamol binding to albumin in blood serum using 2D-IR spectroscopy
Journal article published in 2022 by
Samantha H. Rutherford 
,
Gregory M. Greetham,
Michael Towrie ,
Anthony W. Parker ,
Soheila Kharratian,
Thomas F. Krauss,
Alison Nordon ,
Matthew J. Baker ,
Neil T. Hunt
,
Gregory M. Greetham,
Michael Towrie ,
Anthony W. Parker ,
Soheila Kharratian,
Thomas F. Krauss,
Alison Nordon ,
Matthew J. Baker ,
Neil T. Hunt
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Abstract
Two-Dimensional Infrared (2D-IR) spectroscopy is used to detect binding of paracetamol with proteins in blood serum. Quantitative peak patterns are observed indicating structural changes of the albumins' secondary structure when paracetamol bound.