Published in
Royal Society of Chemistry, Analyst, 11(146), p. 3516-3525, 2021
DOI: 10.1039/d1an00136a
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Mapping sub-cellular protein aggregates and lipid inclusions using synchrotron ATR-FTIR microspectroscopy
Journal article published in 2021 by
David Hartnell 
,
Ashley Hollings,
Anna Maria Ranieri,
Hum Bahadur Lamichhane,
Thomas Becker ,
Nicole J. Sylvain,
Huishu Hou,
M. Jake Pushie ,
Elizabeth Watkin ,
Keith R. Bambery ,
Mark J. Tobin ,
Michael E. Kelly,
Massimiliano Massi ,
Jitraporn Vongsvivut ,
Mark J. Hackett
,
Ashley Hollings,
Anna Maria Ranieri,
Hum Bahadur Lamichhane,
Thomas Becker ,
Nicole J. Sylvain,
Huishu Hou,
M. Jake Pushie ,
Elizabeth Watkin ,
Keith R. Bambery ,
Mark J. Tobin ,
Michael E. Kelly,
Massimiliano Massi ,
Jitraporn Vongsvivut ,
Mark J. Hackett
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Abstract
SR-ATR-FTIR has been used to improve the diffraction limited spatial resolution of infrared micro-spectroscopy, enabling this study to reveal the sub-cellular location of protein aggregates and lipophilic inclusions in brain cells, and bacteria.