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Royal Society of Chemistry, Inorganic Chemistry Frontiers, 2024

DOI: 10.1039/d3qi02032k

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Stepwise optimization of tumor-targeted dual-action platinum(iv)-gemcitabine prodrugs

Journal article published in 2024 by Alexander Kastner ORCID, Theresa Mendrina, Tomer Babu ORCID, Subhendu Karmakar ORCID, Isabella Poetsch, Walter Berger ORCID, Bernhard K. Keppler, Dan Gibson ORCID, Petra Heffeter ORCID, Christian R. Kowol ORCID
This paper was not found in any repository, but could be made available legally by the author.
This paper was not found in any repository, but could be made available legally by the author.

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Abstract

An albumin-binding cisplatin(iv)-gemcitabine complex was step-by-step improved based on stability, reduction, albumin-binding and in vivo data yielding a carboplatin(iv) complex with distinctly improved overall survival and anticancer activity.