Published in
Royal Society of Chemistry, Organic and Biomolecular Chemistry, 13(20), p. 2601-2604, 2022
DOI: 10.1039/d2ob00070a
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Incorporation of Fmoc-Dab(Mtt)-OH during solid-phase peptide synthesis: a word of caution
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Abstract
As a commercially available and orthogonally protected amino acid building block, Fmoc-Dab(Mtt)-OH showed abnormally poor coupling efficiency during solid-phase peptide synthesis (SPPS).