Published in
Royal Society of Chemistry, Food and Function, 19(14), p. 8893-8902, 2023
DOI: 10.1039/d3fo01913f
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Identification and quantification of (poly)phenol and methylxanthine metabolites in human cerebrospinal fluid: evidence of their ability to cross the BBB
Journal article published in 2023 by
Melanie Le Sayec,
Diogo Carregosa 
,
Khadija Khalifa,
Chiara de Lucia ,
Dag Aarsland ,
Cláudia N. Santos,
Ana Rodriguez-Mateos
,
Khadija Khalifa,
Chiara de Lucia ,
Dag Aarsland ,
Cláudia N. Santos,
Ana Rodriguez-Mateos
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Abstract
We investigated the presence of (poly)phenol and methylxanthine metabolites in plasma and cerebrospinal fluid from individuals at risk of dementia suing LC-MS and predicted their mechanism of transport across the BBB using in silico modelling.