Published in
Royal Society of Chemistry, Food and Function, 2023
DOI: 10.1039/d3fo02222f
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Unleashing lactoferrin's antidepressant potential through the PI3K/Akt/mTOR pathway in chronic restraint stress rats
Journal article published in 2023 by
Hanan H. Ahmed 
,
Reham M. Essam ,
Muhammed F. El-Yamany,
Kawkab A. Ahmed ,
Ayman E. El-Sahar
,
Reham M. Essam ,
Muhammed F. El-Yamany,
Kawkab A. Ahmed ,
Ayman E. El-Sahar
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Abstract
The effects of CRS on inducing depression and the beneficial effect of LF in halting depression through mitigating ROS and pro-inflammatory cytokines, restoring corticosterone, 5-HT and BDNF levels, and modulating the hippocampal PI3K/Akt/mTOR/GSK-3β pathway were studied.