Published in
Royal Society of Chemistry, RSC Medicinal Chemistry, 12(13), p. 1621-1633, 2022
DOI: 10.1039/d2md00194b
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Mechanistic insight into the repair of C8-linked pyrrolobenzodiazepine monomer-mediated DNA damage
Journal article published in 2022 by
Asha Mary Joseph 
,
Kazi Nahar,
Saheli Daw,
M.-D. Mahbub Hasan,
M. D. Mahbub Hasan ,
Rebecca Lo,
Tung B. K. Le,
Khondaker Miraz Rahman ,
Anjana Badrinarayanan
,
Kazi Nahar,
Saheli Daw,
M.-D. Mahbub Hasan,
M. D. Mahbub Hasan ,
Rebecca Lo,
Tung B. K. Le,
Khondaker Miraz Rahman ,
Anjana Badrinarayanan
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Abstract
Our understanding about the mode of action of pyrrolobenzodiazepine (PBD) monomers remains incomplete. This study reveals the DNA damaging potential of PBD monomers in bacteria, and identifies mechanisms involved in repair of these PBD-adducts.