Published in
Royal Society of Chemistry, Nanoscale, 44(13), p. 18520-18535, 2021
DOI: 10.1039/d1nr02770k
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Drug delivery, biodistribution and anti-EGFR activity: theragnostic nanoparticles for simultaneousin vivodelivery of tyrosine kinase inhibitors and kinase activity biosensors
Journal article published in 2021 by
Robin Bofinger,
Gregory Weitsman 
,
Rachel Evans ,
Matthias Glaser,
Kerstin Sander ,
Helen Allan ,
Daniel Hochhauser,
Tammy L. Kalber ,
Erik Årstad,
Helen C. Hailes ,
Tony Ng ,
Alethea B. Tabor
,
Rachel Evans ,
Matthias Glaser,
Kerstin Sander ,
Helen Allan ,
Daniel Hochhauser,
Tammy L. Kalber ,
Erik Årstad,
Helen C. Hailes ,
Tony Ng ,
Alethea B. Tabor
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Abstract
We report the development of targeted theragnostic lipid/peptide/DNA lipopolyplexes for delivery of both a tyrosine kinase inhibitor, and plasmid DNA coding for a biosensor. These are used to quantify EGFR inhibition in cancer cell linesin vivo.