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Published in

Royal Society of Chemistry, Organic and Biomolecular Chemistry, 5(21), p. 1000-1007, 2023

DOI: 10.1039/d2ob01911f

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Development of potent tripodal G-quadruplex DNA binders and their efficient delivery to cancer cells by aptamer functionalised liposomes

This paper was not found in any repository, but could be made available legally by the author.
This paper was not found in any repository, but could be made available legally by the author.

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Abstract

Trisubstituted TPA/TPB-based ligands containing linear and macrocyclic polyamines show strong G-quadruplex stabilisation and selectivity over duplex DNA. Encapsulation in AS1411 aptamer-targeted liposomes dramatically increases their cytotoxicity.