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Royal Society of Chemistry, New Journal of Chemistry, 12(46), p. 5515-5525, 2022

DOI: 10.1039/d1nj04087a

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A binuclear Fe(iii)/quinizarin complex as a structural model for anthracycline drugs binding to iron

Journal article published in 2022 by Juliana S. do Nascimento, Aurideia P. de Sousa, Ana C. S. Gondim, Eduardo H. S. Sousa ORCID, Edson H. Teixeira, Luiz Gonzaga do Nascimento Neto, Beatriz Pinheiro Bezerra, Alejandro Pedro Ayala ORCID, Alzir A. Batista ORCID, Igor F. Vasconcelos, Francisco G. S. Oliveira ORCID, Alda K. M. Holanda ORCID
This paper was not found in any repository, but could be made available legally by the author.
This paper was not found in any repository, but could be made available legally by the author.

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Abstract

Quinizarin, an anthracyclin-like compound, was used to prepare a binuclear complex, [(Fe(cyclam))2Qz]Cl(PF6)3, which showed damage to DNA with glutathione. This mimic of anthracyclin drugs might explain undesired side effects of these compounds.