Published in
Royal Society of Chemistry, Dalton Transactions, 5(51), p. 1968-1978, 2022
DOI: 10.1039/d1dt02988f
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Terpyridine copper(ii) complexes as potential anticancer agents by inhibiting cell proliferation, blocking the cell cycle and inducing apoptosis in BEL-7402 cells
Journal article published in 2022 by
Yun-Qiong Gu,
Yu-Jun Zhong,
Mei-Qi Hu,
Huan-Qing Li,
Kun Yang,
Qi Dong,
Hong Liang,
Zhen-Feng Chen 
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Abstract
Four terpyridine copper(ii) complexes were prepared and they showed excellent cytotoxic activity, which induced mitochondrion-mediated apoptosis and cell cycle arrest in the G0/G1 phase. Complex 1 suppressed cell proliferation in vivo.