Published in
Royal Society of Chemistry, Chemical Communications, 63(57), p. 7778-7781, 2021
DOI: 10.1039/d1cc02895b
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A trifunctional self-immolative spacer enables drug release with two non-sequential enzymatic cleavages
Journal article published in 2021 by
Alberto Dal Corso 
,
Simone Arosio,
Noemi Arrighetti ,
Paola Perego ,
Laura Belvisi ,
Luca Pignataro ,
Cesare Gennari
,
Simone Arosio,
Noemi Arrighetti ,
Paola Perego ,
Laura Belvisi ,
Luca Pignataro ,
Cesare Gennari
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Abstract
The enzymatic dephosphorylation of a self-immolative spacer accelerates cargo release and acts as an additional and independent trigger in protease-sensitive prodrugs.