Published in
Royal Society of Chemistry, Biomaterials Science, 9(9), p. 3378-3389, 2021
DOI: 10.1039/d1bm00077b
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Lipid nanoparticles loaded with butamben and designed to improve anesthesia at inflamed tissues
Journal article published in 2021 by
Gustavo H. Rodrigues da Silva 
,
Julia Borges Paes Lemes ,
Gabriela Geronimo,
Fernando Freitas de Lima,
Ludmilla David de Moura ,
Ariany Carvalho dos Santos,
Nathalia Santos Carvalho,
Kauê Franco Malange,
Márcia C. Breitkreitz,
Carlos A. Parada,
Eneida de Paula
,
Julia Borges Paes Lemes ,
Gabriela Geronimo,
Fernando Freitas de Lima,
Ludmilla David de Moura ,
Ariany Carvalho dos Santos,
Nathalia Santos Carvalho,
Kauê Franco Malange,
Márcia C. Breitkreitz,
Carlos A. Parada,
Eneida de Paula
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Abstract
The local anesthetic Butamben was encapsulated in NLC and characterized.In vitrotests showed decreased cytotoxicity andin vivoit improved the anesthesia in inflamed tissue.