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Royal Society of Chemistry, Molecular Omics, 1(18), p. 19-30, 2022

DOI: 10.1039/d1mo00106j

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Targeting coenzyme Q10 synthesis overcomes bortezomib resistance in multiple myeloma

Journal article published in 2021 by Esther A. Zaal ORCID, Harm-Jan de Grooth ORCID, Inge Oudaert ORCID, Pieter Langerhorst, Sophie Levantovsky, Gijs J. J. van Slobbe, Jeroen W. A. Jansen, Eline Menu ORCID, Wei Wu ORCID, Celia R. Berkers ORCID
This paper was not found in any repository, but could be made available legally by the author.
This paper was not found in any repository, but could be made available legally by the author.

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Abstract

This study links CoQ synthesis to bortezomib resistance in multiple myeloma and provides a novel avenue for improving BTZ response through statin-induced inhibition of mitochondrial metabolism.